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Uncomplicated urinary tract infection (not a first-line drug for this indication): 500 mg by mouth every 12 hours for 3 to 7 days or 250 mg by mouth every 6 hours for 3 to 7 days You take one tab/capsule, once every 8 hours. Cephalexin dosage for adults Streptococcal pharyngitis (strep throat): 500 mg by mouth every 12 hours for ten days. Pediatric Patients (over 1 year of age). Uncomplicated urinary tract infection (not a first-line drug for this indication): 500 mg by mouth every 12 hours for 3 to 7 days or 250 mg by mouth every 6 hours for 3 to 7 days No: Reducing the frequency of an antibiotic can reduce its effectiveness for your infection. Try to space the doses evenly throughout the day. Duration of therapy: 7 to 14 days. This keeps the blood drug levels at a more. I have been taking Cephalexin 500 mg 3 times a day since Thursday morning. For Keflex, taking one dose four times daily equates to taking one dose about every. 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